Andreas Guenther Selected Research

KRP-109

1/2016

A small molecule neutrophil elastase inhibitor, KRP-109, inhibits cystic fibrosis mucin degradation.

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Andreas Guenther Research Topics

Disease

20	Idiopathic Pulmonary Fibrosis 12/2022 - 02/2009
18	Fibrosis (Cirrhosis) 01/2022 - 10/2008
12	Pulmonary Fibrosis (Fibrosing Alveolitis) 03/2022 - 09/2009
8	Multiple Myeloma 11/2021 - 01/2010
7	Lung Diseases (Lung Disease) 12/2022 - 02/2009
7	Chronic Obstructive Pulmonary Disease (COPD) 01/2022 - 10/2008
6	Neoplasms (Cancer) 01/2021 - 12/2003
6	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 08/2011 - 07/2007
5	Pneumonia (Pneumonitis) 01/2022 - 07/2007
5	Lung Neoplasms (Lung Cancer) 09/2021 - 11/2009
5	Inflammation (Inflammations) 01/2021 - 12/2003
5	Interstitial Lung Diseases (Interstitial Lung Disease) 10/2019 - 03/2008
4	Hypoxia (Hypoxemia) 01/2022 - 11/2014
4	Pulmonary Hypertension 01/2022 - 01/2004
3	Lung Injury 06/2010 - 12/2003
2	Vascular Remodeling 01/2022 - 01/2022
2	Neoplasm Metastasis (Metastasis) 09/2021 - 02/2011
2	Dyspnea (Shortness of Breath) 11/2020 - 01/2018
2	Hyperplasia 12/2019 - 11/2014
2	Extrinsic Allergic Alveolitis (Hypersensitivity Pneumonitis) 05/2019 - 02/2009
2	Sarcoidosis (Schaumann Disease) 05/2019 - 02/2009
2	Thrombocytopenia (Thrombopenia) 10/2017 - 06/2010
2	Infections 01/2017 - 07/2015
2	Cystic Fibrosis (Mucoviscidosis) 01/2016 - 11/2014
2	Acute Lung Injury 06/2010 - 07/2007
1	Emphysema 01/2022
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 10/2021
1	Carcinogenesis 01/2021
1	COVID-19 01/2021
1	Pathologic Complete Response 01/2020

Drug/Important Bio-Agent (IBA)

11	Bleomycin (Blenoxane)FDA LinkGeneric 03/2022 - 02/2009
5	Peptide Hydrolases (Proteases)FDA Link 07/2015 - 07/2007
4	Transcription Factors (Transcription Factor)IBA 01/2022 - 10/2008
4	Pulmonary Surfactants (Pulmonary Surfactant)IBA 01/2021 - 07/2007
4	Proteins (Proteins, Gene)FDA Link 02/2016 - 10/2007
4	Surface-Active Agents (Surfactants)IBA 07/2015 - 12/2003
3	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2022 - 06/2011
3	EnzymesIBA 01/2022 - 05/2019
3	pirfenidoneIBA 11/2020 - 01/2015
3	RNA (Ribonucleic Acid)IBA 11/2020 - 07/2007
3	Transforming Growth Factors (Transforming Growth Factor)IBA 12/2018 - 11/2009
3	PanobinostatIBA 01/2018 - 02/2016
3	MucinsIBA 01/2016 - 08/2011
3	CollagenIBA 06/2011 - 09/2009
3	FibrinIBA 06/2010 - 10/2007
3	Factor VII (Proconvertin)IBA 03/2008 - 07/2007
2	Histone Deacetylases (Histone Deacetylase)IBA 12/2022 - 11/2015
2	Type 4 Cyclic Nucleotide PhosphodiesterasesIBA 03/2022 - 05/2010
2	Type 6 Cyclic Nucleotide PhosphodiesterasesIBA 01/2022 - 10/2010
2	SmokeIBA 01/2022 - 07/2015
2	Volatile Organic CompoundsIBA 01/2020 - 10/2019
2	Pharmaceutical PreparationsIBA 01/2018 - 06/2011
2	Bortezomib (Velcade)FDA Link 10/2017 - 02/2016
2	Dexamethasone (Maxidex)FDA LinkGeneric 10/2017 - 02/2016
2	Matrix Metalloproteinases (MMPs)IBA 01/2017 - 08/2011
2	LipopolysaccharidesIBA 01/2017 - 11/2014
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2017 - 11/2014
2	Leukocyte Elastase (Neutrophil Elastase)IBA 01/2016 - 07/2015
2	Amiodarone (Amiodarona)FDA LinkGeneric 10/2015 - 11/2014
2	Protein CIBA 07/2015 - 03/2008
2	Hydroxyproline (4 Hydroxyproline)IBA 11/2014 - 07/2010
2	dimethylargininaseIBA 01/2013 - 06/2011
2	Factor VIIa (Activated Factor VII)IBA 06/2011 - 03/2008
2	NitrogenIBA 02/2011 - 01/2010
2	Diphosphonates (Bisphosphonates)IBA 02/2011 - 01/2010
2	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 10/2010 - 05/2010
2	Heparin (Liquaemin)FDA LinkGeneric 06/2010 - 03/2008
2	CytokinesIBA 05/2010 - 11/2009
1	Red DND-99IBA 11/2022
1	CateninsIBA 01/2022
1	Semaxinib (SU5416)IBA 01/2022
1	Insulin-Like PeptidesIBA 01/2022
1	ChromatinIBA 01/2022
1	Tamoxifen FDA LinkGeneric 01/2022
1	Insulin-Like Growth Factor Binding ProteinsIBA 01/2022
1	Tacrolimus Binding Proteins (FKBP)IBA 01/2022
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2022
1	CREB-Binding ProteinIBA 01/2022
1	VaccinesIBA 11/2021
1	TetraspaninsIBA 10/2021
1	Adenylate KinaseIBA 09/2021
1	Versicans (Versican)IBA 01/2021
1	gamma Subunit Interferon-Stimulated Gene Factor 3 (Interferon Stimulated Gene Factor 3, gamma Subunit)IBA 01/2021
1	InterferonsIBA 01/2021
1	Angiotensin Receptor AntagonistsIBA 01/2021
1	Carbon MonoxideIBA 11/2020
1	Long Noncoding RNAIBA 11/2020
1	Membrane Glycoproteins (Membrane Glycoprotein)IBA 01/2020
1	Immunoconjugates (Immunoconjugate)IBA 01/2020
1	EpitopesIBA 01/2020
1	Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA 12/2019
1	Phosphotransferases (Kinase)IBA 12/2019
1	EicosanoidsIBA 05/2019
1	Dinoprostone (PGE2)FDA Link 05/2019
1	Biomarkers (Surrogate Marker)IBA 05/2019
1	IsoprostanesIBA 05/2019
1	8-epi-prostaglandin F2alphaIBA 05/2019
1	ImmunosorbentsIBA 05/2019

Therapy/Procedure

4	Therapeutics 12/2022 - 01/2004
2	Electronic Nose 01/2020 - 10/2019